The LacED integrates information on mutations, sequences, and structures of TEM and SHV ß-lactamases to assign new ß-lactamases, to identify inconsistencies in public databases, and to facilitate protein engineering. Databases of other lactamase classes will be added later.
We acknowledge your comments or contributions, please send us information to be included in the LacED.
beta-Lactamases classD classC classB classA nonTEMnonSHV SHV TEM
This database is maintained by Jürgen Pleiss
Institute of Technical Biochemistry,
University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany


M.Fischer, Q.K.Thai, M.Grieb, J.Pleiss 2006. DWARF - a data warehouse system for analyzing protein families. BMC Bioinformatics 7: 495-495
Q.K.Thai, F.Bos, and J.Pleiss 2009. The Lactamase Engineering Database: a critical survey of TEM sequences in public databases. BMC Genomics 10(1): 390-

We acknowledge Michael Knoll and Florian Wagner for valuable dicussions and their database support.